harlan teklad官網代理商 標準膽固醇 TD.120097 TD.01383 TD.07841 動物飼料
標準的，添加膽固醇的天然成分飲食是用來誘導高膽固醇血癥的。不同水平的膽固醇，脂肪和/或膽汁酸鹽可以添加到眾多的標準嚙齒動物飲食之一，由EnvigoTeclad。在許多應用中，建議將這些成分添加到Envigo的最小到中等植物雌激素的全球嚙齒動物飲食中。我們最小的植物雌激素全球嚙齒動物飲食是不含豆粕的，限制了植物雌激素對你的研究結果的影響。豆粕是一種常見的植物雌激素來源，它可以減少主動脈脂肪條紋的發(fā)育，改善血漿膽固醇，從而降低動脈粥樣硬化的風險。限制飲食豆粕可能會減少飲食誘導動脈粥樣硬化模型中的混雜變量。聯(lián)系營養(yǎng)學家討論其他飲食選擇。
添加膽固醇的最小和中度植物雌激素嚙齒動物飲食的例子：
研究用途：
在轉基因和野生型模型中誘導高膽固醇血癥而不促進肥胖。
主要飲食特征：
- 標準的、以谷物為基礎的嚙齒動物飲食
- 最小/中度植物雌激素飲食建議
- 膽固醇(1-4%)
參考資料：
- 貝爾奇，J，等，對小鼠體內微血管內皮功能的縱向評估。Microvasc RES，2013年。85：P.86-92
- 哈特維森，K，等，飲食誘導高膽固醇血癥小鼠模型研究動脈粥樣硬化無肥胖和代謝綜合征。Arteroscler Thromb VASc Biol，2007年。27(4)：P。878-85
Standard diets with added cholesterol
Standard, natural ingredient diets with cholesterol added are fed to induce hypercholesterolemia. Various levels of cholesterol, fat, and/or bile salts can be added to one of the numerous standard rodent diets stocked by?Envigo Teklad. For many applications, adding these components to Envigo’s minimal-to-moderate phytoestrogen global rodent diets is recommended. Our minimal phytoestrogen global rodent diets are soybean meal free, limiting the effect of phytoestrogens on your research outcomes. Soybean meal, a common dietary source of phytoestrogens, has been shown to decrease aortic fatty streak development and modify plasma cholesterol, which may reduce the risk of developing atherosclerosis. Limiting dietary soybean meal may reduce confounding variables within your dietary-induced atherosclerosis model. Contact a nutritionist to discuss additional diet options.
Examples of minimal and moderate phytoestrogen rodent diets with added cholesterol:
- TD.120097? 1% cholesterol diet (2020 – minimal phytoestrogens)
- TD.07841??? 2% cholesterol diet (2016 – minimal phytoestrogens)
- TD.01383??? 2% cholesterol (2018 – Moderate phytoestrogens)
Research use:
Induce hypercholesterolemia in genetically-modified and wild type models without promoting obesity.
Key dietary features:
- Standard, grain-based rodent diet
- Minimal/moderate phytoestrogen diets recommended
- Cholesterol (1 – 4%)
References:
- Belch, J.J., et al., Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo. Microvasc Res, 2013. 85: p. 86-92.
- Hartvigsen, K., et al., A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol, 2007. 27(4): p. 878-85.
Rabbits, hamsters, and swine are common models of atherosclerosis. Contact a nutritionist for information and formula examples. See?rabbit, swine?and other speciesfor information and formula examples.