harlan teklad官網(wǎng)代理商 標(biāo)準(zhǔn)膽固醇 TD.120097 TD.01383 TD.07841 動(dòng)物飼料
標(biāo)準(zhǔn)的，添加膽固醇的天然成分飲食是用來(lái)誘導(dǎo)高膽固醇血癥的。不同水平的膽固醇，脂肪和/或膽汁酸鹽可以添加到眾多的標(biāo)準(zhǔn)嚙齒動(dòng)物飲食之一，由EnvigoTeclad。在許多應(yīng)用中，建議將這些成分添加到Envigo的最小到中等植物雌激素的全球嚙齒動(dòng)物飲食中。我們最小的植物雌激素全球嚙齒動(dòng)物飲食是不含豆粕的，限制了植物雌激素對(duì)你的研究結(jié)果的影響。豆粕是一種常見(jiàn)的植物雌激素來(lái)源，它可以減少主動(dòng)脈脂肪條紋的發(fā)育，改善血漿膽固醇，從而降低動(dòng)脈粥樣硬化的風(fēng)險(xiǎn)。限制飲食豆粕可能會(huì)減少飲食誘導(dǎo)動(dòng)脈粥樣硬化模型中的混雜變量。聯(lián)系營(yíng)養(yǎng)學(xué)家討論其他飲食選擇。
添加膽固醇的最小和中度植物雌激素嚙齒動(dòng)物飲食的例子：
研究用途：
在轉(zhuǎn)基因和野生型模型中誘導(dǎo)高膽固醇血癥而不促進(jìn)肥胖。
主要飲食特征：
- 標(biāo)準(zhǔn)的、以谷物為基礎(chǔ)的嚙齒動(dòng)物飲食
- 最小/中度植物雌激素飲食建議
- 膽固醇(1-4%)
參考資料：
- 貝爾奇，J，等，對(duì)小鼠體內(nèi)微血管內(nèi)皮功能的縱向評(píng)估。Microvasc RES，2013年。85：P.86-92
- 哈特維森，K，等，飲食誘導(dǎo)高膽固醇血癥小鼠模型研究動(dòng)脈粥樣硬化無(wú)肥胖和代謝綜合征。Arteroscler Thromb VASc Biol，2007年。27(4)：P。878-85
Standard diets with added cholesterol
Standard, natural ingredient diets with cholesterol added are fed to induce hypercholesterolemia. Various levels of cholesterol, fat, and/or bile salts can be added to one of the numerous standard rodent diets stocked by?Envigo Teklad. For many applications, adding these components to Envigo’s minimal-to-moderate phytoestrogen global rodent diets is recommended. Our minimal phytoestrogen global rodent diets are soybean meal free, limiting the effect of phytoestrogens on your research outcomes. Soybean meal, a common dietary source of phytoestrogens, has been shown to decrease aortic fatty streak development and modify plasma cholesterol, which may reduce the risk of developing atherosclerosis. Limiting dietary soybean meal may reduce confounding variables within your dietary-induced atherosclerosis model. Contact a nutritionist to discuss additional diet options.
Examples of minimal and moderate phytoestrogen rodent diets with added cholesterol:
- TD.120097? 1% cholesterol diet (2020 – minimal phytoestrogens)
- TD.07841??? 2% cholesterol diet (2016 – minimal phytoestrogens)
- TD.01383??? 2% cholesterol (2018 – Moderate phytoestrogens)
Research use:
Induce hypercholesterolemia in genetically-modified and wild type models without promoting obesity.
Key dietary features:
- Standard, grain-based rodent diet
- Minimal/moderate phytoestrogen diets recommended
- Cholesterol (1 – 4%)
References:
- Belch, J.J., et al., Longitudinal assessment of endothelial function in the microvasculature of mice in-vivo. Microvasc Res, 2013. 85: p. 86-92.
- Hartvigsen, K., et al., A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol, 2007. 27(4): p. 878-85.
Rabbits, hamsters, and swine are common models of atherosclerosis. Contact a nutritionist for information and formula examples. See?rabbit, swine?and other speciesfor information and formula examples.